Figure 4.

LKB1 is required to maintain epithelial polarity under energetic starvation conditions. (A) lkb1^4A mutant follicle cell clones under normal (left) or energetic stress conditions (right). Mutant cells are marked by the absence of GFP (green) and visualized with the same markers (at left) as described in Fig. 2 A. (B) lkb⁴ clone stained for DNA (blue) and Dlg (red, left) or DECad (red, right). Large mutant clones at the anterior or posterior poles of the egg chamber overproliferate to form tumorlike aggregates of unpolarized cells.