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. 2007 May 7;177(3):401–411. doi: 10.1083/jcb.200607133

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Copyright © 2007, The Rockefeller University Press

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Figure 4. — Histone methylation and acetylation levels in mutant ES cells. (A) Western blots of proteins from WT, Dnmt3 ⁻, Dnmt3 ^−res, Dnmt1 ⁻, and MeCP2 ⁻ ES cells incubated with antibodies that detect H3K9me2, H3K9me3, H3K9ac, H4K5ac, H4K16ac, HP1α, and H3. GAPDH is shown as a control. (B) Mean (±SEM [error bars]) levels of histone modifications detected in the different mutant ES cells normalized relative to GAPDH and WT (n = 3 or 4). (C and D) Abundance (C) and concentration (per kilobase; D) of H3K9me2, H3K9me3, and H3K9ac modifications detected by ChIP at different repeats in WT (white bars) and Dnmt3 ⁻ (gray bars) cells. h.p., high passage; l.p., low passage.