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. 2007 Jul 30;178(3):465–476. doi: 10.1083/jcb.200702009

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Copyright © 2007, The Rockefeller University Press

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Figure 2. — Phenotypes and somite patterning of embryos with various Dll1 and Dll3 allele combinations. (A) Embryo appearance (top) and skeletal preparations (bottom) of E18.5 embryos with the genotypes indicated on top. Dll1 ^Dll3HA/+ embryos (a–c) have an essentially normal axial skeleton despite an increased gene dosage ratio of Dll3 to Dll1. Skeletal defects of homozygous Dll3-null mutants (d–f) are rescued by Dll3HA expressed from the Dll1 locus (g–i) except for minor residual defects (i, arrowheads). Increased gene dosage ratio of Dll3 to Dll1 does not enhance a hypomorphic Dll1 phenotype (compare p–r with s–u). Note that modification of the Dll1 locus does not lead to any phenotypic alterations in the skeleton (m–o). (B) A-P somite patterning at E9.5 indicated by Uncx4.1 expression and dynamic Lfng expression patterns are indistinguishable in wild-type (a–c) and Dll1 ^Dll3HA/+ embryos (g–i). Abnormal expression of Uncx4.1 and Lfng in homozygous Dll3^pu-null mutants (d–f) is restored by Dll3HA expressed from the Dll1 locus (m–o) except for minor irregularities of Uncx4.1 expression (m, arrowhead). Expression of Dll3HA instead of Dll1 (j–l) does not rescue the patterning defects of Dll1-null mutants (p–r).