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. 2007 Jul 30;178(3):465–476. doi: 10.1083/jcb.200702009

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Copyright © 2007, The Rockefeller University Press

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Figure 3. — NICD expression in the PSM of Dll3 mutant embryos. Whole-mount immunohistochemistry for activated Notch 1 (NICD) readily detected oscillating activity in E10.5 embryo wild-type tails (A–C; n = 13). In Dll1-null mutant tails (D), NICD was not detected in the PSM (n = 4), whereas in Dll3-null mutant tails (E–G), the pattern of Notch1 activity is static (n = 14) with no obvious up-regulation of NICD protein levels.