Table 6.

Cox proportional hazards analysis of SEP-based classification

Training dataset	Tested on all 286 patients		Tested on 209 ER+ patients
	Hazard ratio (95% CI)	p value	Hazard ratio (95% CI)	p value
Rosetta	1.85 (1.26–2.74)	0.0019	1.97 (1.25–3.10)	0.0031
Combined	1.81 (1.23–2.66)	0.0028	2.42 (1.52–3.87)	0.0002

The 60-gene profiles obtained from the training datasets were validated by all and ER-positive patients in Veridex dataset. Patients were grouped using the median SEP score as threshold.