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. Author manuscript; available in PMC: 2007 Nov 7.
Published in final edited form as: Toxicol Appl Pharmacol. 2007 Mar 23;221(2):215–221. doi: 10.1016/j.taap.2007.03.009

Figure 3. Involvement of CYP 2E1 in 1,2-VCM - induced ovotoxicity in ovarian cultures.

Figure 3

Ovaries from PND4 B6C3F1, CYP 2E1 +/+ or -/- mice were cultured with medium control or 1,2-VCM (125, 250, 500, 750, or 1000 μM) for 15d. Following incubation, ovaries were collected, and processed for histological evaluation as described in materials and methods. Healthy (A) primordial, and (B) primary follicles were classified and counted. Values are mean ± SE total follicles counted/ovary, n=5; different letters differ (p<0.05) from one another within each follicle type.