Table 2.
Distribution (mean ± SD) of amino acids linked to the L-arginine-nitric oxide pathway in sickle cell disease patients with tricuspid regurgitant jet velocity (TRV) < 2.5 m/s, 2.5 – 2.99 m/s, and ≥ 3.0 m/s, and in normal controls.
| Variable | NL Control (n=36) |
All SCD (n=209) |
p* | TRV<2.5 (n=131) |
2.5-2.99 (n=53) |
TRV≥3.0 (n=21) |
p** |
|---|---|---|---|---|---|---|---|
| Arginine | 67 (18) | 41 (16) | < .001 | 41 (16) | 41 (15) | 39 (15) | .51 |
| Ornithine | 62 (22) | 65 (23) | .38 | 63 (21) | 65 (25) | 81 (24) | .003 |
| Proline | 154 (59) | 210 (75) | < .001 | 202 (70) | 219 (80) | 245 (88) | .01 |
| Citrulline | 25 (11) | 25 (13) | .85 | 23 (12) | 26 (15) | 27 (14) | .09 |
| Arg/Orn | 1.20 (.49) | .71 (.39) | < .001 | .74 (.41) | .72 (.39) | .49 (.18) | .03 |
| Arg/(Orn+Cit) | .82 (.27) | .50 (.26) | < .001 | .53 (.27) | .50 (.26) | .36 (.13) | .02 |
*
P-values are from two-sided two-sample t-test.
**
P-values are from linear regression on level of TRV, coded 0,1,2.