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. 2007 Oct 1;4:70. doi: 10.1186/1742-4690-4-70

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Copyright © 2007 Brügger et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Elevation of SM/PC ratios is insufficient for Nef-mediated enhancement of virion infectivity. (A) Single round of infection analysis on TZM cells with cell culture supernatants from MT-4 T lymphocytes infected with the indicated viruses. The assay was performed analogous to that described in Fig. 1A. (B) Quantitative lipid analysis of virion SM/PC ratios. HIV particles purified from the cell culture supernatants analyzed in A were subjected to lipidome analysis. Depicted are the SM to PC ratios.