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. Author manuscript; available in PMC: 2008 Aug 1.
Published in final edited form as: Cell Calcium. 2007 Mar 21;42(2):193–203. doi: 10.1016/j.ceca.2007.02.007

Figure 3.

Figure 3

Activation of CRAC-like current in cultured C. elegans intestinal cells. (A) An inwardly rectifying CRAC-like current activates when Ca2+ stores are depleted by inclusion of 10 μM IP3 in the patch pipette solution. Currents were elicited by ramping membrane voltage from −120 mV to +80 mV at 200 mV/sec every 5 sec. (B) Inwardly rectifying whole-cell currents elicited by stepping membrane voltage from −120 mV to +80 mV from a holding potential of 0 mV. Steps were 400 msec in duration. Currents were measured after store depletion induced activation was complete. (C) Changes in whole cell current observed in the absence of store depletion (open circles), during passive store depletion (solid circles), and during active store depletion induced by IP3 (solid squares).