Table 3.
The odds of ≥1 increase and decrease in BI-RADS mammographic breast density category relative to no change in breast density category by statin use
| Statin use* | Decrease in breast density
|
Increase in breast density
|
||
|---|---|---|---|---|
| Unadjusted OR (95% CI) | Adjusted OR (95% CI)† | Unadjusted OR (95% CI) | Adjusted OR (95% CI)† | |
| Nonuser | 1.0 (reference) | 1.0 (reference) | 1.0 (reference) | 1.0 (reference) |
| Discontinuer | 1.1 (0.6–2.0) | 1.1 (0.6–2.0) | 1.4 (0.8–2.5) | 1.3 (0.8–2.3) |
| Initiator | 0.9 (0.7–1.2) | 1.0 (0.7–1.2) | 1.0 (0.8–1.3) | 1.0 (0.7–1.2) |
| Continuer | 1.0 (0.9–1.2) | 1.0 (0.9–1.2) | 1.2 (1.0–1.4) | 1.1 (0.9–1.3) |
| Any use | 1.0 (0.9–1.1) | 1.0 (0.9–1.2) | 1.1 (1.0–1.3) | 1.0 (0.9–1.2) |
We defined nonusers as women who were not using statins at either screen, discontinuers as users of statins at the 1st screen but nonusers at the 2nd screen, initiators as nonusers of statins at the 1st screen but users of statins at the 2nd screen, continuers as users of statins at both screens; and any use as women who were dispensed ≥2 statins during year before 2nd screen.
Odds ratios compared with no change group and adjusted for age (continuous), BMI (continuous), change in BMI (≥1 kg/m2 increase or decrease and no change), hormone therapy use (nonuser, current, discontinuer), and time between screens (continuous).