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. Author manuscript; available in PMC: 2008 Oct 12.
Published in final edited form as: Mol Cell. 2007 Oct 12;28(1):134–146. doi: 10.1016/j.molcel.2007.09.009

Figure 2. Ctp1 is Essential for Meiosis and for HR Repair of DSBs in Mitotic Cells.

Figure 2

(A) Asci from a ctp1Δ × ctp1Δ mating are abnormal. DNA is stained with DAPI.

(B) Spore viability in a ctp1Δ × ctp1Δ mating is very low. This defect is partially suppressed in a rec12Δ background that is unable to form programmed meiotic DSBs.

(C) Ctp1 is required for HR but not NHEJ. HR was measured by integration of a transformed linearized plasmid into homologous sequences. NHEJ was measured by circularization of a transformed linearized plasmid. Values are calculated with respect to transformants obtained with an uncut plasmid and are normalized to wild type.