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Dose-dependent tethering stimulation of FAK phosphorylation. Serum-starved HT1080 cells were plated on antibody substrates formed from the binding of mixtures of AG89 diluted with different proportions of 9E10 that were bound to nitrocellulose-coated surfaces. Specific phosphorylation of Y861 and Y397 is shown as a function of antibody-ligand density. Error bars, SEM for n = 3. Linear regression: pY397 R2 = 0.96, p < 0.0001; pY861 R2 = 0.99, p < 0.0001.
