Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Signaling through TLR4. TLRs are dimers which signal Myd88 and TIRAP (not shown) to induce the MAP kinase cascade and activation of NF-κB. These molecules induce the transcription of a variety of inflammatory mediators. Certain TLRs are known to require soluble cofactors for recognition, such as LPS binding protein (LBP), CD14, and MD-2.
