Table 5.
Total amount [nmol/vial] of drug related compounds in human lung tissue slices
| Incubation time [h] | Parent compound | Active compound | Fatty acid esters | Inactive metabolite | |
| Beclomethasone | 2 | 2.19 ± 0.83 | 7.88 ± 2.21 | 0.90 ± 0.46 | 0.38 ± 0.06 |
| dipropionate2 | 6 | 0.72 ± 0.46 | 7.78 ± 3.80 | 0.50 ± 0.40 | 1.89 ± 0.49 |
| 24 | - | 2.73 ± 2.22 | 0.87 ± 0.96 | 5.72 ± 1.20 | |
| Budesonide1 | 2 | 7.32 ± 0.99 | 3.17 ± 2.00 | - | |
| 6 | 8.41 ± 2.15 | 5.39 ± 4.03 | - | ||
| 24 | 9.04 ± 1.14 | 8.91 ± 5.15 | - | ||
| Ciclesonide | 2 | 6.46 ± 0.92 | 0.76 ± 0.2 | 0.40 ± 0.20 | - |
| 6 | 8.86 ± 1.68 | 2.17 ± 0.51 | 1.10 ± 0.73 | - | |
| 24 | 9.53 ± 1.70 | 7.61 ± 1.31 | 7.29 ± 3.79 | - | |
| Fluticasone1 | 2 | 8.42 ± 1.26 | - | - | |
| propionate | 6 | 8.62 ± 2.20 | - | - | |
| 24 | 9.51 ± 2.22 | - | - | ||
Data are presented as mean ± standard deviation (n = 9).
1Parent and active compound.
2The active compound of BDP may be overestimated as inactive 21-BMP may be included.