Table 3.
Putative regulatory elements in the 5’ flanking region of the dual clip-domain serine proteinase genesa
| Regulatory element (consensus sequence) | HP12 | HP24b | PAP-2 | PAP-3 | PPAEb |
|---|---|---|---|---|---|
| TATA box (TATAT or TATAAA) | +TATATA (−79) | +TATATA (−67) | +TATAAA (−88) | +TATAAA (−39) | |
| +TATATA (−64) | +TATATA (−65) | ||||
| +TATAAA (−29) | |||||
| GATA (WGATAA) | +AGATAA (−928) | −AGATAA (−641) | +AGATAA (−880) | +TGATAA (−536) | +AGATAA (−699) |
| −AGATAA (−323) | +TGATAA (−869) | +AGATAA (−145) | −TGATAA (−562) | ||
| +AGATAA (−537) | |||||
| +TGATAA (−375) | |||||
| +TGATAA (−205) | |||||
| ISRE (GGAAANNGAAANN) | +aGAtAGAGAAAC (−877) | −AGAAAATGAgAAT (−725) | −GtAAAGAcAAAAA (−810) | −GtAAACTGAtACA (−944) | +GGAAATTaAACG (−871) |
| +GgcAAGGGAcAG (−566) | −TcAAATCGAAAAA (−478) | +GGAAAATGAccTC (−441) | −TGAAtTTGAAATT (−292) | +GGAAAAAcAAAA (−315) | |
| +GGAAAGGGctAA (−421) | +GGAAtACcAAACA (−432) | +GGAAcCGGAtATA (−334) | +GGgcACGGAAAAG (−213) | −GaAAATAGAAAT (−293) | |
| +GGAAACAGtAcG (−384) | −GgtAAGCGAtACG (−360) | +GGAAtGCGAcACA (−307) | +aGAAgGAGAAACT (−193) | −GGAAAATGAtAC (−125) | |
| +GtAAAACcAAATT (−310) | |||||
| +GcAAAATtAAAAA (−182) | |||||
| NF-κB (GGGRAYYYYY) | +GGGAAaTCTT (−944) | −GcGGACTCTC (−781) | −GGGGACTTCT (−1765) | −GaGAATCCTT (−68) | |
| +GGGtATTTTT (−807) | +GGGGATTaCT (−190) | +GGcAATTCCC (−1018) | |||
| +tGGGATCTCC (−350) | +aGGGACTTCC (−152) | +GGaGATTCTC (−427) | |||
| EcRE (RRGKTCANTGAMCYY) | +cGGGaaAATGACCTC (−443) | +AGtTTgAATGcACTT (−291) | |||
| −GAGGTCATTttCCCg (−431) | +AGGTTCAGTGcgCgT (−6) |
a
Mismatches are shown in lower case letter.
b
Nucleotide positions (in parentheses) are relative to the predicted transcriptional initiation site.