TABLE 1.

Ten most significant model parameters

Rank	Parameter	Meaning
1	kf,5	Rate constant for the phosphorylation of active receptor.
2	Ls	Full-strength ligand concentration during stimulation.
3	kf,4	Rate constant for the binding of ligand to precoupled receptor.
4	kf,16	Rate constant for the degradation of IP3.
5	Rpc	Ratio of plasma membrane surface area to cytosolic volume.
6	Gd	Area density of free inactive G-protein.
7	Kd,2	Dissociation constant for the precoupling of receptor.
8	kf,14	Rate constant for the nonstimulated IP3 production reaction.
9	kf,8	Forward rate constant for the binding of calcium to PLCβ.
10	kr,8	Reverse rate constant for the binding of calcium to PLCβ.