Skip to main content
PMC home page
British Journal of Experimental Pathology logoLink to British Journal of Experimental Pathology
. 1972 Apr;53(2):125–129.

Encephalopathy in Mice Following Inapparent Semliki Forest Virus (SFV) Infection

I Zlotnik, D P Grant, Dee Batter-Hatton
PMCID: PMC2072546  PMID: 5032088

Abstract

The avirulent “A8” strain of S.F.V. gave rise to acute lesions of encephalitis in mice within 7 days of infection. After 6 weeks, however, all signs of disease disappeared from the brain, but when such animals were destroyed 2 years later they had advanced lesions of hydrocephalus, spongy degeneration and above all a severe astrocytic reaction in many centres of the brain. No such lesions were observed either in animals inoculated with formolinactivated virus, or in uninoculated controls of the same age.

Full text

PDF

Images in this article

126-1Figs. 1-4
on p.126-1
126-3Figs. 5-7
on p.126-3
126-5Figs. 8-10
on p.126-5

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bradish C. J., Allner K., Maber H. B. The virulence of original and derived strains of Semliki forest virus for mice, guinea-pigs and rabbits. J Gen Virol. 1971 Aug;12(2):141–160. doi: 10.1099/0022-1317-12-2-141. [DOI] [PubMed] [Google Scholar]
  2. Daniel P. M. Transmissible degenerative diseases of the nervous system. Proc R Soc Med. 1971 Jul;64(7):787–794. [PMC free article] [PubMed] [Google Scholar]
  3. Eckroade R. J., Zu Rhein G. M., Marsh R. F., Hanson R. P. Transmissible mink encephalopathy: experimental transmission to the squirrel monkey. Science. 1970 Sep 11;169(3950):1088–1090. doi: 10.1126/science.169.3950.1088. [DOI] [PubMed] [Google Scholar]
  4. Gajdusek D. C., Gibbs C. J., Jr, Alpers M. Transmission and passage of experimenal "kuru" to chimpanzees. Science. 1967 Jan 13;155(3759):212–214. [PubMed] [Google Scholar]
  5. Henderson D. W., Peacock S., Randles W. J. On the pathogenesis of Semliki forest virus (SFV) infection in the hamster. Br J Exp Pathol. 1967 Apr;48(2):228–234. [PMC free article] [PubMed] [Google Scholar]
  6. MCINTOSH B. M., WORTH C. B., KOKERNOT R. H. Isolation of Semliki Forest virus from Aedes (Aedimorphus) argenteopunctatus (Theobald) collected in Portuguese East Africa. Trans R Soc Trop Med Hyg. 1961 Mar;55:192–198. doi: 10.1016/0035-9203(61)90025-6. [DOI] [PubMed] [Google Scholar]
  7. Pattison I. H., Jebbett J. N. Clinical and histological observations on cuprizone toxicity and scrapie in mice. Res Vet Sci. 1971 Jul;12(4):378–380. [PubMed] [Google Scholar]
  8. Seamer J., Zlotnik I. Louping-ill and Semliki forest virus infections in the short-tailed vole Microtus agrestis (L.). Br J Exp Pathol. 1970 Aug;51(4):385–393. [PMC free article] [PubMed] [Google Scholar]
  9. Zlotnik I., Barlow R. M. The transmission of a specific encephalopathy of mink to the goat. Vet Rec. 1967 Jul 8;81(2):55–56. doi: 10.1136/vr.81.2.55. [DOI] [PubMed] [Google Scholar]
  10. Zlotnik I., Carter G. B., Grant D. P. The persistence of louping ill virus in immunosuppressed guinea-pigs. Br J Exp Pathol. 1971 Aug;52(4):395–407. [PMC free article] [PubMed] [Google Scholar]
  11. Zlotnik I., Smith C. E., Grant D. P., Peacock S. The effect of immunosuppression on viral encephalitis, with special reference to cyclophosphamide. Br J Exp Pathol. 1970 Aug;51(4):434–439. [PMC free article] [PubMed] [Google Scholar]
  12. Zlotnik I. The reaction of astrocytes to acute virus infections of the central nervous system. Br J Exp Pathol. 1968 Dec;49(6):555–564. [PMC free article] [PubMed] [Google Scholar]

Articles from British Journal of Experimental Pathology are provided here courtesy of Wiley

RESOURCES