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Properties of the mutant proteins
| Construct | Mutation | dmin, Å | ΔA, Å2 | R(acrylodan) | R(CNBD) | R(IANBD) | Kd, μM | Kd(IANBD), μM |
|---|---|---|---|---|---|---|---|---|
| Wild-type | — | — | — | — | — | — | 0.9 | — |
| A1 | Phe-92 → Cys | 15 | +51 | 1.5 | 0.92 | 0.84 | 0.6 | 0.3 |
| A2 | Ile-329 → Cys | 11 | +37 | 1.0 | 1.0 | 1.8 | 1.0 | 0.1 |
| B1 | Asn-100 → Cys | 19 | +50 | 0.85 | 1.0 | 1.0 | 1.0 | — |
| B2 | Arg-98 → Cys | 17 | +31 | 1.0 | 1.0 | 1.05 | 1.1 | — |
| B3 | Asp-95 → Cys | 17 | +52 | 0.8 | 1.0 | 4.4 | 1.5 | 1.4 |
| C1 | Ser-233 → Cys | 14 | −48 | 0.85 | 1.4 | 2.0 | 2.0 | 11.0 |
