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. 2007 Aug 3;115(11):1631–1637. doi: 10.1289/ehp.10216

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LM histology of IHC rat embryonic striatum. Confluent cultures of embryonic were exposed to 5 ppm P25 for 6–48 hr, IHC stained with NSE and morphometrically analyzed. (A) Untreated cultures consisted of a dense plexus of neurons and glia. (B) Axonal beading and cellular granularity were seen as early as 6 hr postexposure. (C) Evidence of apoptosis (circles) was documented by 24 hr. (D) Complete disruption and loss of cellular integrity was noted by 48 hr postexposure to 5 ppm P25.