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. Author manuscript; available in PMC: 2007 Nov 9.
Published in final edited form as: J Biol Chem. 2006 Jun 16;281(33):23302–23306. doi: 10.1074/jbc.C600143200

FIGURE 2. Stabilization of the stem loop reduces the 4R to 3R ratio.

FIGURE 2

HeLa cells were transfected with minigenes (A) that expressed each of six tau stem loops. Quantitative RT-PCR (B) revealed that the ratio of 4R to 3R tau was reduced to the extent that the mutations stabilized the stem loop. C, relative amounts of 4R and 3R PCR products reflect the ratio of tau 4R and 3R isoforms quantitated by RT-PCR.