Changes in body composition in testosterone-treated HIV-infected men and women. Meta-analysis plots of contrasts between androgen-treated and placebo-treated HIV-infected men with weight loss, showing the change in whole body mass (A), and lean body mass (B) and HIV-infected women with weight loss, showing the change in whole body mass (C) and fat-free mass (D). A positive difference is a favorable testosterone effect on body mass, lean body mass, and fat-free mass. Some studies reported fat-free mass and some lean body mass. Fat-free mass equals lean body mass plus bone mineral content. Confidence intervals that do not overlap with zero represent significant differences between placebo and testosterone groups.