Table 2.
Map of P2 receptor modulation after dopamine denervation
| Ipsilateral Striatum | Ipsilateral SN | |
|---|---|---|
| P2X1 | = | ↑GABA |
| P2X2 | ↓GABA | ↓TH |
| P2X3 | ↓GABA | ↓TH, ↑GABA |
| P2X4 | ↓GABA | ↓TH, ↑GABA |
| P2X5 | = | ↓TH |
| P2X6 | = | ↓TH, ↑GABA |
| P2X7 | = | = |
| P2X1 | = | ↓TH |
| P2X2 | = | = |
| P2X4 | ↓GABA | ↑GFAP |
| P2X6 | = | ↓TH |
| P2X11 | = | = |
| P2X12 | = | = |
| P2X13 | = | = |
| P2X14 | = | ↓TH |
Relative increase (↑) or decrease (↓) in P2X and P2Y receptor proteins analyzed by confocal immunofluorascence microscopy in striatum and SN after treatment in rat in vivo with 6-hydroxydopamine (ipsilateral), and in control (not lesioned) brain hemisphere (contralateral).TH= presence in dopaminergic neurons,GABA= presence in GABAergic neurons,GFAP= presence in astrocytes