Figure 1.

Human karyopherin β3 is homologous to yeast Kap121p and human karyopherin β1. (A) The amino acid sequence of human karyopherin β3 (hβ3) was aligned with that of Kap121p (yβ3) by the Clustal method using the Multiple Sequence Alignment module of the Lasergene software (dnastar). The aligned sequences were imported into SeqVu 1.1 (Garvan Institute) to highlight homologies (boxed sequences) and identities (shaded sequences); the setting used for homologies was GES scale at 85%. (B) The amino acid sequences of human karyopherin β1 and β3 were aligned as in A. (C) Comparison of Ran binding regions in RanBP1 (32), human karyopherin β1 (21) and β3; the numbers indicate amino acid positions.