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. Author manuscript; available in PMC: 2008 Mar 1.
Published in final edited form as: Dev Biol. 2006 Nov 21;303(1):391–404. doi: 10.1016/j.ydbio.2006.11.025

Figure 6. Ctgf expression is down-regulated in the perichondrium of the Meckel’s cartilage in Tgfbr2fl/fl;Wnt1-Cre mice.

Figure 6

(A–D) In situ hybridization of Ctgf in the perichondrium of Meckel’s cartilage at E12.5 and E13.5 in control and Tgfbr2fl/fl;Wnt1-Cre mice. There is a significant reduction of Ctgf expression in Tgfbr2fl/fl;Wnt1-Cre mice at E12.5 and E13.5 (arrowheads, A–D). (E) Quantitative analysis of Ctgf mRNA expression by real time quantitative RT-PCR in Meckel’s cartilage at E13.5. Ctgf expression is dramatically decreased in Tgfbr2fl/fl;Wnt1-Cre mutant samples. Asterisks indicate statistical significance (p<0.01). Scale bar: 200μm in A–D