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. Author manuscript; available in PMC: 2008 Mar 1.
Published in final edited form as: Dev Biol. 2006 Nov 21;303(1):391–404. doi: 10.1016/j.ydbio.2006.11.025

Figure 8. CTGF is a downstream mediator of TGF-β signaling to control cell proliferation in Meckel’s cartilage.

Figure 8

BrdU labeling of cultured Meckel’s cartilage from control and Tgfbr2fl/fl;Wnt1-Cre mice at E12.5, treated with BSA, TGF-β2 or CFGF beads for 24 hours (E12.5+1). (A,C,D) Control sample treated with BSA and TGF-β2 beads. The number of BrdU labeled cells (red arrows) is much greater in Meckel’s cartilage treated with TGF-β2 beads. (B,E,F) Tgfbr2fl/fl;Wnt1-Cre sample treated with BSA and CTGF beads. The Tgfbr2fl/fl;Wnt1-Cre sample has few labeled cells with BSA beads but many more after treatment with CTGF beads (red arrows). (G) Schematic drawing demonstrates that TGF-β controls CTGF expression in the perichondrium to regulate chondrocyte proliferation during Meckel's cartilage development. Scale bar: 100μm in A–F.