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Screening of 14,000 natural products with antibiotic biomarker strains
| Biomarker | Reference antibiotic | MIC of reference antibiotic [μM (μg/ml)] | Maximal signal induction by reference antibiotic (%) | SD (%) | Z′ factor | Detection cutoff (%) | Minimal signal-inducing concn of reference antibiotic at detection cutoff (μM) | No. (%) of confirmed hits |
|---|---|---|---|---|---|---|---|---|
| yheI | Linezolid | 3.13 (0.93) | 980 | 13 | 0.84 | 200 | 0.1 | 26 (0.2) |
| yorB | Ciprofloxacin | 0.71 (0.25) | 1,380 | 9 | 0.87 | 250 | 0.06 | 12 (0.1) |
