Table 1.
Genes activated 3, 6 or 24 hours after treatment with PBS (P) or IFN-γ (I) aerosol for 10 min., then intranasal PBS (P) or CAPs (C) 3 hours later.
Gene | PP* | PC | IP | IC | Fold increase (IC/PP) | Fold increase (IC/PC) | Fold increase (IC/IP) |
---|---|---|---|---|---|---|---|
3 hours | |||||||
MIP-1a | 0.047 | 0.104 | 0.091 | 0.113 | 2.38 | 1.09 | 1.24 |
MIP-3b | 0.038 | 0.062 | 0.041 | 0.083 | 2.19 | 1.34 | 2.02 |
MIP-1b | 0.048 | 0.083 | 0.042 | 0.101 | 2.09 | 1.22 | 2.40 |
TECK | 0.036 | 0.053 | 0.057 | 0.066 | 1.85 | 1.25 | 1.16 |
MDC | 0.062 | 0.083 | 0.064 | 0.103 | 1.66 | 1.24 | 1.61 |
IL17B | 0.094 | 0.126 | 0.126 | 0.146 | 1.56 | 1.16 | 1.16 |
6 hours | |||||||
TARC | 0.031 | 0.115 | 0.041 | 0.143 | 4.66 | 1.24 | 3.49 |
MCP-5 | 0.017 | 0.063 | 0.035 | 0.073 | 4.30 | 1.16 | 2.09 |
Lungkine | 0.474 | 0.872 | 0.743 | 1.108 | 2.34 | 1.27 | 1.49 |
MIP-1g | 0.052 | 0.104 | 0.073 | 0.111 | 2.11 | 1.07 | 1.52 |
IL-9 | 0.028 | 0.035 | 0.035 | 0.055 | 1.98 | 1.57 | 1.57 |
IL-1b | 0.047 | 0.063 | 0.041 | 0.079 | 1.68 | 1.25 | 1.93 |
24 hours | |||||||
IL-8Rb | 0.015 | 0.024 | 0.025 | 0.047 | 3.07 | 1.96 | 1.88 |
MIP-1g | 0.047 | 0.084 | 0.065 | 0.124 | 2.62 | 1.48 | 1.91 |
C-10 | 0.477 | 0.895 | 0.680 | 0.981 | 2.06 | 1.10 | 1.44 |
IL-1b | 0.042 | 0.035 | 0.052 | 0.085 | 2.03 | 2.43 | 1.63 |
CCR-1 | 0.020 | 0.020 | 0.022 | 0.040 | 2.03 | 2.00 | 1.82 |
MIP-3a | 0.084 | 0.123 | 0.127 | 0.142 | 1.69 | 1.15 | 1.12 |
CCR-2 | 0.056 | 0.045 | 0.061 | 0.084 | 1.5 | 1.87 | 1.38 |
Densitometric value Glossary: MIP1a = macrophage inflammatory protein 1 alpha; MIP3b = macrophage inflammatory protein 3 beta; MIP1b = macrophage inflammatory protein 1 beta; TECK = thymus-expressed chemokine; MDC = macrophage-derived chemokine; IL17B = interleukin 17B; TARC = thymus and activation regulated chemokine; MCP-5 = monocyte chemotactic protein 5; MIP-1g = macrophage inflammatory protein 1g; IL-9 = interleukin 9; IL-1b = interleukin 1 beta; IL-8Rb = interleukin 8 receptor b; C-10 = chemokine 10; CCR-1 = chemokine receptor 1; MIP-3a = macrophage inflammatory protein 3 alpha; CCR-2 = chemokine receptor 2.