Table 3.
Permanent increase of the ratio [EPSC drive/(EPSC + IPSC) drive] during epileptogenesis
Glutamatergic Drive (pC s−1) | GABAergic drive (pC s−1) | Ratio (%) | ||||
---|---|---|---|---|---|---|
Soma | ||||||
Sham | 0.95 ± 0.22 | (13) | 13.1 ± 2.7 | (13) | 6.3 ± 1.2 | (13) |
Early latent (3–5 days) | 0.29 ± 0.07* | (13) | 7.09 ± 1.08* | (13) | 3.8 ± (0.9)* | |
Late latent (7–10 days) | 3.65 ± 0.66*† | (12) | 13.9 ± 1.9† | (12) | 20.9 ± 2.1*† | (12) |
Chronic | 6.78 ± 1.44*† | (9) | 29.3 ± 5.1*† | (9) | 20.7 ± 3.8* | (9) |
Dendrites | ||||||
Sham | 0.56 ± 0.15 | (8) | 10 ± 3.5 | (8) | 4.9 ± 1.7 | (8) |
Latent | 2.69 ± 0.68* | (6) | 5.3 ± 1.0* | (6) | 32.7 ± 5.1* | (6) |
Chronic | 2.32 ± 0.57† | (8) | 3.5 ± 0.8*† | (8) | 40.9 ± 5.3* | (8) |
Values represent means ±s.e.m.
P < 0.05, significantly different by Student's unpaired t test compared with sham.
P < 0.05, significantly different by Student's unpaired t test comparing chronic versus late latent (7–10 days) and late latent (7–10 days) versus early latent (3–5 days).