Table 2.
Chimera name | Figure | n | ND96 | HCO3–CO2 | Cotransport current | |||
---|---|---|---|---|---|---|---|---|
END96 | GND96 (μS) | EHCO3 | GHCO3 (μS) | ENBC | GNBC (μS) | |||
water | Fig. 1A | 5 | −41.0 ± 5.6 | 1.1 ± 0.1 | −47.4 ± 6.6 | 0.8 ± 0.1 | −27.7 ± 2.8 | −0.4 ± 0.1 |
NBCe1-A | Fig. 1B | 7 | −36.5 ± 1.2 | 7.7 ± 0.9 | −91.5 ± 2.8 | 24.0 ± 1.4 | −129.3 ± 4.5* | 12.5 ± 0.9** |
NBCn1-B | Fig. 1C | 7 | −33.4 ± 5.1 | 5.9 ± 0.3 | −26.2 ± 0.5 | 4.7 ± 0.2 | −23.7 ± 1.8 | −1.3 ± 0.3 |
n1(Nt)/e1 | Fig. 3 | 7 | −43.2 ± 2.4 | 3.2 ± 0.4 | −98.9 ± 4.8 | 6.0 ± 0.6 | −156.3 ± 9.2* | 3.0 ± 0.4** |
n1(L)/e1 | — | 6 | −37.9 ± 2.2 | 4.9 ± 0.5 | −100.3 ± 2.5 | 14.3 ± 0.9 | −140.9 ± 6.4* | 11.1 ± 0.7** |
n1(Ct)/e1 | — | 7 | −43.2 ± 2.1 | 3.0 ± 2.1 | −113.1 ± 1.9 | 9.8 ± 1.1 | −123.8 ± 1.6* | 9.7 ± 1.2** |
n1(NtLCt)/e1 | Fig. 4 | 5 | −38.0 ± 2.5 | 1.9 ± 0.1 | −94.0 ± 3.9 | 5.7 ± 0.6 | −120.9 ± 3.3* | 3.7 ± 0.6** |
e1(Nt)/n1 | Fig. 5 | 7 | −27.2 ± 0.4 | 6.1 ± 0.3 | −27.9 ± 0.4 | 5.2 ± 0.3 | −24.9 ± 2.0 | −0.9 ± 0.9 |
e1(L)/n1 | — | 7 | −30.9 ± 1.1 | 6.3 ± 0.5 | −33.0 ± 1.1 | 4.9 ± 0.3 | −22.6 ± 1.2 | −1.3 ± 0.2 |
e1(Ct)/n1 | — | 6 | −30.4 ± 1.3 | 4.1 ± 0.3 | −33.6 ± 3.0 | 3.1 ± 0.5 | −23.5 ± 3.3 | −0.9 ± 0.3 |
e1(NtLCt)/n1 | Fig. 6 | 7 | −33.3 ± 0.9 | 5.6 ± 1.1 | −37.8 ± 1.0 | 3.9 ± 0.9 | −23.2 ± 0.8 | −1.7 ± 0.3 |
n1(1–821)/e1 | Fig. 7 | 8 | −30.5 ± 2.2 | 1.3 ± 0.2 | −32.3 ± 2.5 | 0.9 ± 0.2 | −26.4 ± 1.6 | −0.4 ± 0.1 |
n1(822–1218)/e1 | Fig. 8 | 7 | −30.3 ± 0.6 | 7.7 ± 1.0 | −32.5 ± 0.8 | 6.4 ± 0.9 | −20.8 ± 1.2 | −1.3 ± 0.2 |
Conductance (G) was computed from current–voltage (I–V) values crossing the zero currents.
Significant compared to water-injected controls (P < 0.05).