Figure 3. Burst-LTD and intracellular Ca²⁺.

A and B, EPSP amplitude–time series with sample traces (A) and normalized population data (B) of burst-pairing experiments during intracellular application of BAPTA (30 mm, n = 8). C and D, EPSP amplitude–time series with sample traces (C) and normalized 1 min time-averaged population data (D) of burst-pairing experiments in the presence of the inositol 1,4,5-trisphosphate receptor blocker heparin added to the pipette solution (1 mg ml⁻¹, n = 7). E and F, comparable experiments in the presence of ruthenium red (0.2 mm) to block ryanodine receptors (n = 6). Dashed lines and bars represent average control values and the pairing period, respectively.