Figure 4. Effects of octreotide on the mechanosensory responses of jejunal afferent nerves in WT and sst2 KO mice.

A, representative traces of mean discharge frequency and intraluminal pressure (IP) to illustrate the nerve responses to jejunal distension and bradykinin before and following bath-application of octreotide (25 μg in 3 ml Krebs solution superfused over 20 s). B, bar graph to illustrate the effects of octreotide on low- (pressure range, 0–10 mmHg) and high-threshold (pressure range, 10–60 mmHg) mechanosensory responses in WT and sst2 KO mice. Note that whereas octreotide inhibited both low- and high-threshold mechanosensory responses in WT mice, in the KO it only inhibited the low-threshold response. *P < 0.05; **P < 0.01, paired Student's t test, n = 7 for each group.