Figure 2. Whole-cell submandibular acinar K currents in K_Ca3.1- and K_Ca1.1- and double-null mice.

A, whole-cell currents in a cell from K_Ca3.1-null mouse recorded with 250 nm Ca²⁺ in the pipette. Currents were recorded immediately after achieving whole-cell mode (Early and ^) and after a steady level of IK1 current developed (Later and •) and after addition of 1 μm paxillin, a maxi-K channel inhibitor (▴). Typical raw traces and average I–V plot are presented in the same format as in Fig. 1B (n = 7). B and C, same as described in A but currents recorded in cells from K_Ca1.1-null mice (n = 5) and from double-null mice (n = 7). B, the identity of the developed current was tested by addition of 3 μm clotrimazole, the specific inhibitor of IK1 channel (▴).