Figure 7. Muscarinic-stimulated saliva secretion from isolated submandibular glands.

A, saliva secretion from ex vivo submandibular glands from either wild-type or K_Ca3.1-null mice, the artery and main excretory duct cannulated. Secretion was stimulated by vascular perfusion with 0.5 μm CCh: •– wild-type, ^–K_Ca3.1-null glands (n = 8 and 9 mice, respectively). B and C, same as described for A but fluid flow rates were compared in K_Ca1.1-null (n = 5 mice) and double-null (n = 5 mice) glands with their wild-type controls (n = 4 and n = 4 mice, respectively).