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Analysis of PI4K11α over expression phenotype
| WT | TG | n | |
|---|---|---|---|
| Body weight | 26 ± 2 g | 28 ± 6 g | 10 |
| Heart weight | 0.22 ± 0.01 g | 0.39 ± 0.06 g | |
| Heart/body (%) | 0.83 ± 0.1% | 1.7 ± 0.3% | |
| Isolated heart | |||
| frequency (35°C) | 185 ± 12 min−1 | 180 ± 15 min−1 | 3 |
| PIP | 0.46 ± 0.05% | 0.60 ± 0.04% | 10 |
| PIP2 | 0.41 ± 0.04% | 0.61 ± 0.04% | 9 |
| PI4P-ase* (%) | 100% | 180% | 2 |
PI4P phosphatase activity.
