Figure 3. Temporal summation of NMDA-R and AMPA-R mediated EPSPs evoked at different holding potentials.

Responses to 50 Hz pulse train stimulation of retinal afferents. A, temporal summation of NMDA-R mediated EPSPs. Traces in grey, responses in the control condition before blockade of AMPA-Rs. Traces in black, responses after blockade of AMPA-Rs with 10 μm NBQX. B, temporal summation of AMPA-R mediated EPSPs. Traces in grey, responses in the control condition before blockade of NMDA-Rs. Traces in black, responses after blockade of NMDA-Rs with 10 μm CPP. Voltage dependent sodium spikes were blocked by QX222 added to the intracellular solution. Each trace is the average of five repetitive train stimulations. Data in A and B are from two different cells.