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. 2007 May 17;582(Pt 1):27–39. doi: 10.1113/jphysiol.2007.134288

Figure 8. Channels formed by the assembly of N-terminal domain TMD0 of SUR1 and Kir6.2ÄC36 are largely insensitive to block by Rho123.

Figure 8

A and B, inside-out patch clamp records from Xenopus oocytes coexpressing TMD0(SUR1) and Kir6.2ΔC36 illustrating the response to 10 μm Rho123 in the presence of 100 μm ATP (A) and in nucleotide-free (B) solutions. C, average currents for Kir6.2, SUR2A + Kir6.2, and TMD0(SUR1) + Kir6.2ΔC36 channels measured before (grey bars) and after (black bars) application of 10 μm Rho123 in the presence of 100 μm ATP. Currents were normalized to the current measured in 0 ATP before application of blocker. D, equivalent data but in nucleotide-free conditions E, data from C and D expressed as percentage inhibition. Numbers above each bar indicate the number of patches included in the average.