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. 2007 May 17;582(Pt 1):279–296. doi: 10.1113/jphysiol.2007.133751

Figure 13. Summary diagram of synaptic inputs to ipRGCs.

Figure 13

Schematic diagram summarizing the synaptic circuits inferred from results of the present study. Amacrine cells can evoke inhibitory light responses in ipRGCs at light onset, whereas ON and OFF bipolar cells can trigger excitatory light responses in ipRGCs at light onset and offset, respectively. Synaptic inputs from the ON bipolar cells appear to cover the entire ipRGC dendritic field, and thus might include both conventional ON bipolar cells contacting proximal dendrites of ipRGCs in the ON sublamina of the inner plexiform layer (middle bipolar) and atypical ON bipolar cells making synaptic contacts in the OFF sublamina (right bipolar). ‘+’ and ‘−’ symbols represent excitatory and inhibitory receptors, respectively. ONL, outer nuclear layer; OPL, outer plexiform layer; INL, inner nuclear layer; IPL, inner plexiform layer; GCL, ganglion cell layer; OFF BC, OFF bipolar cell; ON BC, ON bipolar cell; AC, amacrine cell; ipRGC, intrinsically photosensitive retinal ganglion cell.