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. 2007 Apr 19;582(Pt 1):113–125. doi: 10.1113/jphysiol.2007.133660

Figure 2. Effects of bath applications of non-AMPA glutamate receptor antagonists on drive potential generation and XII motor output.

Figure 2

A, APV (50 μm) attenuates inspiratory bursts, but has no effect on XII motor output. B, the mGluR1 antagonist LY367385 (LY; 15 μm) attenuates inspiratory bursts, but has no effect on XII motor output. C, the mGluR5 antagonist MPEP (10 μm) attenuates inspiratory bursts, but has no effect on XII motor output. D, the general group II mGluR antagonist APICA (300 μm) significantly reduces the frequency of XII motor output but has no effect on inspiratory bursts. In A–D, arrows indicate inspiratory bursts shown at high time resolution in the insets at right. Voltage calibration bars in the insets apply to all traces in A–D. Individual time calibration bars are illustrated for traces and insets. Baseline membrane potential was −60 mV.