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. 2007 Mar 15;582(Pt 2):489–506. doi: 10.1113/jphysiol.2007.130302

Figure 6. Spontaneous transient outward currents (STOCs) are reduced in UBSM cells of RyR2+/−.

Figure 6

STOCs in UBSMCs from RyR2+/+ and RyR2+/− were measured at holding potentials from −60 to −30 mV at 10 mV step under whole-cell patch clamp. A, representative recordings of STOCs at −30 mV in RyR2+/+ and RyR2+/− UBSMCs. B and C, summarized data of frequency (B) and amplitude of STOCs (C) at −30 mV in UBSMCs from RyR2+/+ (^) and RyR2+/− (•). D, distribution histogram of STOC events against the amplitude in each 10 pA bins over 20 pA. Original data were obtained at a holding potential of −30 mV in UBSMCs from RyR2+/+ (^) and RyR2+/− (•). E, charge displacement due to STOCs at a holding potential of −30 mV. B–E, numerals in parentheses indicate the number of cells examined. *P < 0.05 versus RyR2+/+.