Figure 4. Protection of the ICC-MY network after intestinal resection by genetic disruption of iNOS.
A–D, ICC-MY networks adjacent to (0.5 cm) and at 1.0, 3.0 and 5.0 cm from the site of anastomosis. In iNOS−/− mice, the ICC-MY network was slightly damaged only near the site of the anastomosis. ICC-MY appeared normal and similar to cells in sham-operated animals (see Fig. 2E) in all other samples examined. D, scale bar represents 50 μm, and applies to A–D.