Figure 4. Ventilation, tidal volume and breathing frequency averaged over the last 2 min of the normoxic period prior to the hypoxic periods for the four time periods in both the hypoglycaemic and hyperglycaemic clamps.

Ventilation showed a significant increase during the clamp periods for both hypoglycaemia and hyperglycaemia but the frequency was increased for hypoglycaemia and tidal volume was increased for hyperglycemia. Statistical testing (see Methods): *significantly different from Pre-Clamp value; +significantly different from Post-Clamp value.