Figure 11. The increase in unstimulated${\text{Ca}}_{\text{i}}^{2+}$ and the decrease in peak ${\text{Ca}}_{\text{i}}^{2+}$ were smaller and slower in control conditions than in the presence of glibenclamide.

Mean changes in unstimulated and peak ${\text{Ca}}_{\text{i}}^{2+}$ during fatigue at 37°C in control (A) and glibenclamide (10 μm) wild-type FDB single fibres (B). Symbols:^, •, control wild-type unstimulated and peak ${\text{Ca}}_{\text{i}}^{2+}$, respectively; □, ▪, glibenclamide (10 μm) wild-type unstimulated and peak ${\text{Ca}}_{\text{i}}^{2+}$, respectively. Vertical bars represent the s.e.m. of 13 control and 19 glibenclamide fibres from 9 wild-type mice. *Time (with horizontal line) when peak ${\text{Ca}}_{\text{i}}^{2+}$ of glibenclamide fibres was significantly different from control fibres, ANOVA and lsd,P < 0.05. §Mean unstimulated or peak ${\text{Ca}}_{\text{i}}^{2+}$ significantly different from mean value at time 0, ANOVA and lsd,P < 0.05.