Figure 12. In Kir6.2^−/− FDB fibres, the increase in unstimulated${\text{Ca}}_{\text{i}}^{2+}$ and the decrease in peak ${\text{Ca}}_{\text{i}}^{2+}$during fatigue at 37°C were also extensive while glibenclamide had no effect.

Mean changes in unstimulated and peak ${\text{Ca}}_{\text{i}}^{2+}$ in control (A) and glibenclamide (10 μm) Kir6.2^−/− FDB fibres (B). Symbols: ▵, ▴, control Kir6.2^−/− unstimulated and peak ${\text{Ca}}_{\text{i}}^{2+}$, respectively; ⋄, ♦, glibenclamide Kir6.2^−/− unstimulated and peak ${\text{Ca}}_{\text{i}}^{2+}$, respectively. Vertical bars represent the s.e.m. of 11 control and 10 glibenclamide fibres from 6 Kir6.2^−/− mice. §Mean unstimulated and peak ${\text{Ca}}_{\text{i}}^{2+}$ significantly different from mean value at time 0, ANOVA and lsdP < 0.05.