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. 2007 Apr 26;582(Pt 2):629–646. doi: 10.1113/jphysiol.2007.133561

Figure 3. Purkinje cells remain innervated by multiple climbing fibres in TrkB mutant mice.

Figure 3

A, plots of climbing fibre response (CFR) amplitude versus stimulus intensity from Purkinje cells of P20–24 wild-type (a), fBZ/fBZ (b), and Wnt1Cre;fBZ/fBZ (c) cerebella. The lower right insets are representative of the CFRs used to generate the plots. Scale bars: vertical, 200 pA; horizontal, 10 ms. The upper left insets depict paired pulse depression upon climbing fibre activation. Scale bars: vertical, 250 pA; horizontal, 10 ms. B, the percentage of Purkinje cells recorded with 1, 2, 3 or 4 CFRs (steps) at P3–5 (a), P12–14 (b), and P20–24 (c). (P3–5: n= 15 wild-type cells, n= 11 fBZ/fBZ cells, and n= 6 Wnt1Cre;fBZ/fBZ cells; P12–14: n= 19 wild-type cells, n= 26 fBZ/fBZ cells, and n= 15 Wnt1Cre;fBZ/fBZ cells; P20–24: n= 71 wild-type cells, n= 68 fBZ/fBZ cells, and n= 52 Wnt1Cre;fBZ/fBZ cells). At P12–14 (Bb) and P20–24 (Bc), a larger percentage of Purkinje cells retain multiple innervation in the TrkB mutant (fBZ/fBZ and Wnt1Cre;fBZ/fBZ) mice as compared with the wild-type mice (P12–14: χ2= 15.9, *P < 0.001; P20–24: χ2= 18.9, *P < 0.001 by χ2 test).