Figure 3. Examples of serosal/mesenteric afferent responses on application of 5-HT (10 μm) for 3 min in spontaneously active fibres.

Control (A), a dextran sulphate sodium (DSS)-treated animal (B) and animal following recovery (C). A–C, upper traces show rate of nerve firing (bin size, 2 s). The lower traces show a raw record of nerve activity, with one active fibre evident. 5-HT was introduced over the period indicated by first arrows, and was washed out at the point shown by second arrows. Note increase in size of response in B and C compared with control (A).