Figure 6. TLR5/IL-10DKO mice show high colonic expression of IL-17 and severe colitis.

(A) TLR5/IL-10DKO mice and IL-10KO littermates were followed for incidence of rectal prolapse. Mice were euthanized upon developing prolapse, which always correlated with clear gross evidence of colitis. (B) Colons from indicated rectally prolapsed mice were isolated within 24 hours of prolapse and cultured in vitro for 24 hours; IL-17 production was measured by ELISA. *P < 0.05.