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. 2006 Dec 21;580(Pt 2):373–383. doi: 10.1113/jphysiol.2006.123570

Figure 1. Tonic activation of NMDA receptors in hippocampal neurons.

Figure 1

A, bath application of the NMDAR antagonist d-AP5 (50 μm) blocks a tonic current in a CA1 pyramidal neuron held at +40 mV. B, current–voltage relationship of the d-AP5-sensitive tonic current. C, NMDAR antagonists 7-chlorokynurenate (7-ClKyn, 10 μm), d-AP5 (50 μm), and MK801 (40 μm) significantly reduce the tonic current while the AMPA/kainate receptor antagonist NBQX (20 μm), the inhibitor of the AMPA receptor desensitization cyclothiazide (CTZ, 100 μm), and the metabotropic glutamate receptor antagonist LY 341495 (LY, 100 μm) have no effect on the holding current. In all figures, the holding potential was +40 mV and * indicates a P < 0.05.