Table 1.
Human peptides with sequence homology to B. burgdorferi OspA165−173a
|
Major T Cell Contact Sites |
P2 |
P5 |
P8 |
Accession # |
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| B. burgdorferi OspA165−173 | Y | V | L | E | G | T | L | T | A | NP_045688 |
| Human Homologues | ||||||||||
| Eight identical residues | ||||||||||
| MAWD-BP280−288b | V | " | " | " | " | " | " | " | " | NP_071412 |
| Six identical residues | ||||||||||
| T-span760−68c | " | " | " | I | " | " | G | " | T | NP_004606.2 |
| Ornithine Decarboxylase Inhibitor28−36 | " | " | Y | " | H | " | " | " | G | NP_680479 |
| Sorting Nexin 1621−629 | " | " | " | " | S | K | " | " | E | NP_722523.1 |
| Five identical residues | ||||||||||
| Ubiquitination Factor E4B341−349 | L | " | " | Q | " | S | " | " | Q | NP_006039 |
| Carnitine Transporter492−500d | " | I | " | M | " | S | " | " | I | NP_003051 |
| SOS-1444−452e | F | I | M | " | " | " | " | " | R | NP_005624.2 |
| Mitochondria P Carrier318−326f | I | I | M | I | " | " | " | " | " | NP_002626.1 |
| EMAP-1525−533g | F | " | " | Q | " | " | " | S | G | NP_004425 |
| Transmembrane NMB303−311h | " | " | " | N | " | " | F | S | L | NP_002501 |
| LFA-1332−340i | " | " | I | " | " | " | S | K | Q | NP_002200 |
| IL-1 Receptor accessory472−480 | " | " | " | Q | " | " | Q | A | L | NP_002173.1 |
| Pleckstrin homology domain324−332 | L | " | " | " | " | " | F | R | I | NP_001025055 |
| Erythroid Factor76−84 | " | " | " | " | " | L | K | F | V | AAC00001.1 |
| SHIP-2987−995j | " | " | " | " | " | V | P | H | Q | NP_001558.2 |
| LSP-1180−188k | L | " | " | " | " | " | I | E | Q | NP_002330 |
| ATP Binding Cassette530−538 | " | " | " | F | " | " | Y | I | I | NP_005680.1 |
a
Only peptides with a compatible P1 anchor residue (hydrophobic or aromatic) and no more than a single substitution at one of the major T cell contact sites are shown.
b
MAPK activator with WD-repeats binding protein
c
Tetraspanin 7
d
aka Solute carrier family 22 member 5
e
Son of Sevenless homolog 1
f
aka Solute carrier family 25 member 3 isoform b precursor
g
Echinoderm microtubule associated protein like 1 isoform b
h
glycoprotein nonmetastatic melanoma protein B
i
Integrin alpha L
j
Inositol polyphosphate phosphatase-like 1
k
lymphocyte-specific protein 1 isoform