Table 2.
Ki (nM ± SEM) for binding of peptides to R190/N192, R190/K192, or W190/N192 FPR
| R190/N192 | R190/K192 | W190/N192 | |
|---|---|---|---|
| Formyl-NleLeuPhe | 67 ± 16 | 62 ± 8 | 160 ± 25⁎⁎ |
| MMWLL | 330 ± 50 | 190 ± 30 | 840 ± 200⁎ |
| HKU coronavirus peptides | |||
| MYVKWPWYVWL | 783 ± 50 | 837 ± 32 | 263 ± 9⁎⁎ |
| Formyl-MYVKWPWYVWL | 134 ± 9 | 134 ± 12 | 133 ± 8 |
| SARS coronavirus peptides | |||
| 36mer | 3,270 ± 250 | 3,140 ± 150 | 770 ± 25⁎⁎ |
| 12 mer (EQYIKWPWYVWL) | 2,050 ± 107 | 2,400 ± 170 | 390 ± 30⁎⁎ |
| Coronavirus OC43 peptide | |||
| 36mer | 850 ± 80 | 740 ± 80 | 460 ± 50⁎⁎ |
| Coronavirus 229E peptides | |||
| 36 mer | 10,000 ± 1400 | 6,800 ± 670 | 1300 ± 60⁎⁎ |
| 12 mer (ETYIKWPWWVWL) | 533 ± 30 | 370 ± 30 | 270 ± 10⁎⁎ |
| LWVWWPWKIYTE (reverse) | > 50,000 | > 50,000 | > 50,000 |
| WPWWVWL | ∼ 600 | ∼ 600 | ∼ 600 |
| WWVWL | ∼ 1000 | ∼ 1400 | ∼ 600 |
| ETYIKWP | > 260,000 | > 260,000 | > 260,000 |
| HIV-1 peptides | |||
| 36 mer | 1500 ± 80 | 820 ± 50 | 960 ± 200 |
| 12 mer (ELDKWASLWNWF) | 1200 ± 100 | 940 ± 150 | 1050 ± 100 |
| HIV-2 peptides | |||
| 37 mer | 15,700 ± 1000 | 10,000 ± 1200 | 4000 ± 1000⁎⁎ |
| 12 mer (KLNSWDVFGNWF) | 15,000 ± 2000 | 9,500 ± 2000 | 4700 ± 290⁎⁎ |
| Ebola peptide | |||
| 12 mer (NDNWWTGWRQWI) | 1400 ± 200 | 1200 ± 90 | 1200 ± 150 |
⁎
P < 0.05 W190/N192 vs. either R190/N192 or R190/K192.
⁎⁎
P < 0.01 W190/N192 vs. either R190/N192 or R190/K192.