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. 2003 Nov;23(21):7658–7666. doi: 10.1128/MCB.23.21.7658-7666.2003

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Copyright © 2003, American Society for Microbiology

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FIG. 6. — Embryonic malformations in embryos lacking both Cited2 and INK4a/ARF. (A through D) Hematoxylin- and eosin-stained transverse sections from Cited2^+/+:INK4a/ARF^−/− and Cited2^−/−:INK4a/ARF^−/− embryos at 14.5 dpc. Scale bars, 0.1 mm. Axes: d, dorsal; v, ventral; r, right; l, left. (A) Transverse section through the thorax of a Cited2^+/+:INK4a/ARF^−/− embryo shows normal cardiac anatomy. The interatrial septum (ias) separates the right (ra) and left (la) atria. The right (rv) and left (lv) ventricles are separated by a normal interventricular septum (ivs) (B) Corresponding section of a Cited2^−/−:INK4a/ARF^−/− embryo shows a ventricular septal defect (VSD). (C) Transverse section through the abdomen of a Cited2^+/+:INK4a/ARF^−/− embryo showing normal right (rad) and left (lad) adrenal glands and left kidney (lk). (D) Corresponding section of a Cited2^−/−:INK4a/ARF^−/− embryo shows lack of right and left adrenal glands. (E and F) Cranial development in Cited2^+/+:INK4a/ARF^−/− and Cited2^−/−:INK4a/ARF^−/− embryos at 14.5 dpc. Scale bar, 1 mm. (E) Cited2^+/+:INK4a/ARF^−/− embryo showing normal cranial development. (F) Cited2^−/−:INK4a/ARF^−/− embryo showing exencephaly.